ABSTRACT
INTRODUCCTION: Methemoglobinemia (MetaHb) is a condition where the erythrocyte is unable to release oxygen into tissues causing tissue hypoxia and metabolic acidosis with high lactate. In adult patients with SARS-CoV2 infection, some cases of coexistence of MetaHb and refractory hypoxemia have been reported;although there are no reports of this association in the neonatal stage. CLINICAL CASES: We show two cases of premature newborns with SARS-CoV-2 infection who had multisystemic deterioration and MetaHb in the second to the thrid week of life, without microbiological isolation, or temperary relationship with known MetaHb triggers, normal G6PD levels, and partial response to exchange transfusion or infusion of methylene blue. CONCLUSION: The relationship between MetaHb and SARS-CoV-2 infection is still unknown, but its pro-inflammatory activity has recently been documented, which can increase cytokine storm and worsen the evolution and prognosis of the patient with moderate to severe infection. Further studies of these associations are therefore necessary to enable timely interventions. © 2023 Instituto Nacional de Pediatria. All rights reserved.
ABSTRACT
Neonatal asphyxia and its complications remain a serious problem at birth;the knowledge and skills of those who apply the Neonatal Resuscitation Program have an impact on the morbidity and mortality of the newborn. Recently, the International Liaison Committee on Resuscitation (ILCOR) has published new recommendations on neonatal resuscitation to improve outcomes in newborns, as well as methodology for provider education. It also contains a section on care during the COVID-19 pandemic. This article presents a summary of the most important changes in the book Neonatal Resuscitation, eighth edition, published in 2021 by the American Heart Association and the American Academy of Pediatrics. © 2021 Sociedad Mexicana de Pediatria. All rights reserved.